School of Biomedical Sciences
FaCULty of Medicine
The Chinese University of Hong Kong
Research
Harnessing tumor heterogeneity and circumventing therapeutic resistance in liver cancer
Mission
WE AIM TO
identify the molecular determinants of tumor heterogeneity from both cell-autonomous and non-cell-autonomous perspectives. Our research focus and efforts point towards an understanding of an intertwined relationship between metabolic heterogeneity, cellular stress responses in response to therapy and remodeling of tumor microenvironment in liver cancer.
Research Interest
1. Metabolic heterogeneity and aberrations in cancer
2. Resistance mechanism to cancer therapies
3. Bidirectional interaction between tumor microenvironment and cancer cells
4. Novel and rational combination therapies for effective cancer treatment
5. Biology of cancer stem cells
Research Directions
Tumor heterogeneity
Research platform
Pre-clinical models
Hydrodynamic tail vein injection (HTVI)
HCC patient derived xenografts (PDX)
Diet induced HCC mouse model
HCC patient-derived organoids
Muti-omics
Transcriptome
Proteomics
Metabolomics
